Endocrine Abstracts

Background: The relationships between thyroid hormones (TH) and platelets (PLT) have not been fully established. Physiological concentrations of L-thyroxine (T4) activate human PLT resulting in ATP release and aggregation. On the other hand, subclinical hypothyroidism has been frequently associated with hypercoagulability, in particular mean platelet volume (MPV), a marker of platelet activation, has been found higher in patients with subclinical hypothyroidism. A possible pro...

Introduction: Obesity is a chronic disease, significantly influenced by maladaptive eating patterns. Oxytocin (OT), recognized for its central role in regulating energy metabolism and eating behavior, represents a potential link in understanding this intricate relationship.Objective: This study aimed to investigate the potential association between circulating levels of OT and maladaptive eating behaviors, assessed through the Eating Behaviors Assessment...

Background: Oxytocin (OXT) enhances glucose uptake and lipid utilization in adipose tissue and skeletal muscle.Dysfunction of the OXT system could underlie the pathogenesis of weight gain. Men and women with obesity were reported to have higher OXT blood levels compared to normal weight subjects. In contrast, metabolic syndrome has been associated with reduced fasting serum oxytocin in larger scale mixed gender studies.Aim: Data regarding the oxytocin sy...

Introduction: Metabolically associated fatty liver disease (MAFLD), prevalent in the Western world and a leading cause of liver transplantation among U.S. women, ranges from intra-hepatocyte lipid accumulation to cirrhosis. Fibrosis severity is crucial for prognosis, correlating with risks of advanced cirrhosis, portal hypertension, and hepatocellular carcinoma. 5-10% weight loss is associated with improvement of liver steatosis, but achieving >10% weight loss is usually n...